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  1. A once-daily oral dosage form composition for daytime and nighttime control of symptoms of histamine release, the dosage form comprising a non-sedating antihistamine component and a sedating antihistamine component comprising the combination of an antihistamine and sedative, wherein the two antihistamines are released at different times. The composition defined in claim 1 wherein the sedating antihistamine is selected from the group consisting of brompheniramine, chlorpheniramine, debrompheniramine, dexchlorpheniramine, carbinoxamine, clemastine, diphenhydramine, pyrilamine, tripelennamine, tripolidine, methdilazine, bromodiphenhydramine, promethazine, azatadine, cyproheptadine, diphenylpyraline, doxylamine, trimeprazine, phenindamine, ketotifen, hydroxyzine, tazifylline, temelastine, meclizine, acrivastine, setastine, oxatomide, mequitazine, levocabastine, lodoxamide, AHR 11325, phenindamine, azelastine, and ebastine, or a pharmaceutically acceptable salt thereof. The composition defined in claim 1 wherein the non-sedating antihistamine is selected from the group consisting of fexofenadine, loratadine, descarboethoxy loratadine, astemizole, norastemizole, desmethylastemizole, cetirizine, acrivastine, and temelastine, or a pharmaceutically acceptable salt thereof. The composition of claim 1 wherein the sedative is selected from the group consisting of antidepressants, hypnotics, and anxiolytics. The composition of claim 1 further comprising a leukotriene receptor antagonist for enhanced control of symptoms. The composition defined in claim 1 which further comprises a therapeutically effective amount of at least one agent selected from the group consisting of an analgesic agent, an antitussive agent, an expectorant, an anti-inflammatory agent, an anti-pyretic agent and a decongestant. The composition of claim 1 wherein the oral dosage form is selected from the group consisting of tablets, capsules, liquids, emulsions, and suspensions. The composition of claim 1 comprising: (a) a therapeutically effective amount of at least one sedating compound, sufficient to produce sedating effects, and optionally sufficient to inhibit histamine release symptoms, which becomes effective at a first time between about the time of administration and about the first two hours after administration, and which has a sedative effect for a first duration selected from the range of about 1 hour to about 12 hours, and (b) a therapeutically effective amount of a non-sedating antihistamine formulated to inhibit histamine release whenever no other antihistamine is present; wherein the non-sedating antihistamine is formulated to provide a delayed release beginning at a second time in the interval of about 1 to about 10 hours after ingestion, and continuing in effect for a second duration that is sufficient to provide an effective antihistamine effect for at least about 18 hours or more after ingestion. The composition of claim 7 wherein the sedating antihistamine has a duration of activity if about 6 to 10 hours. The composition of claim 1, comprising a delayed release coating on the non-sedating antihistamine. The composition of claim 10, wherein the delayed release coating is selected from the group consisting of ethyl cellulose, cellulose acetate, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, acrylic acid polymers and copolymers, polymers or copolymers of methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, ethyl methacrylate, hydroxypropyl methylcellulose acetate succinate, shellac, cellulose acetate trimellitate, vinyl acetate, azo polymers, pectin, chitosan, amylose, guar gum, and zein or combination thereof. The composition of claim 1, wherein the non-sedating antihistamine accumulates with repeated administration so that the antihistamine effect of the compound administered, together with that any circulating active metabolites thereof, is approximately continuous at or near a level within the therapeutic range. The composition of claim 1, which comprises: (a) a therapeutically effective amount of a non-sedating antihistamine formulated to inhibit histamine release symptoms beginning within about the first two hours after administration and continuing for a duration of about 10 hours to about 30 hours; and (b) a therapeutically effective amount of a sedating antihistamine compound, sufficient to produce sedating effects, and optionally to inhibit histamine release symptoms, for a duration of about 4 hours to about 12 hours; wherein the sedating antihistamine compound is formulated to provide a delayed release beginning at about 12 to about 18 hours after ingestion and providing sedation for a period ranging from about 1 hour to about 8 hours, the intervals selected so that the composition is no longer effective as a sedative at about 24 hours after ingestion; and wherein the delayed release is achieved by coating at least one drug-containing core, resin or granulation with at least one delayed release control polymer. The composition of claim 13 wherein the delayed release control polymer is selected from the group consisting of ethyl cellulose, cellulose acetate, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, acrylic acid polymers and copolymers, polymers or copolymers of methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, ethyl methacrylate, hydroxypropyl methylcellulose acetate succinate, shellac, cellulose acetate trimellitate, vinyl acetate, azo polymers, pectin, chitosan, amylose, guar gum, and zein and combinations thereof. The composition of claim 13, wherein the non-sedating antihistamine accumulates with repeated administration so that the antihistamine effect of the non-sedating antihistamine combined with its active metabolites is approximately continuous at a level within the therapeutic range. The composition of claim 1 in daily oral uni-dosage or divided dosage form, designed for administration upon awakening, which comprises: (a) a therapeutically effective amount of a non-sedating antihistamine formulated to inhibit histamine release for a first duration in the range of about 16 hours or more, beginning at a selected time in the range of about the first two hours after ingestion; and (b) a therapeutically effective amount of a sedating antihistamine, to produce sedating effects beginning at a time in the range of about 12 hour of ingestion to about 18 hours after ingestion, and continuing for a second duration in the range of about 2 hours to about 10 hours, the times selected so that the sedative effect ceases at about 24 hours after ingestion; wherein the delayed release is achieved by coating at least one core or granulation with at least one delayed release control polymer. The composition of claim 16 wherein the delayed release control polymer is selected from the group consisting of ethyl cellulose, cellulose acetate, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, polyvinyl acetate phthalate, acrylic acid polymers and copolymers, polymers or copolymers of methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, ethyl methacrylate, hydroxypropyl methylcellulose acetate succinate, shellac, cellulose acetate trimellitate, vinyl acetate, azo polymers, pectin, chitosan, amylose, guar gum, and zein and combinations thereof. The composition of claim 16, wherein the non-sedating antihistamine accumulates with repeated administration so that the antihistamine effect of the non-sedating antihistamine combined with its active metabolites is approximately continuous at a level within the therapeutic range. A method of inhibiting the release of histamine in a patient which comprises the step of administering to a patient, a therapeutically effective amount of the composition defined in claim 1. The method of inhibiting the release of histamine defined in claim 19 wherein the antihistamine composition is administered during the evening or night and the sedating antihistamine is immediately released. The method of inhibiting the release of histamine defined in claim 19 wherein the patient suffers from allergic reaction, allergic rhinitis, cold or flu. The older antihistamines (first generation antihistamines) are associated with troublesome sedative and anti-muscarinic effects and are often called sedating antihistamines.