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Rate of c Gv HD was 11% for the whole population and 14% for the TKI alone cohort.
Background: In contrast to imatinib, data on the use of 2 generation tyrosin kinase inhibitors (TKI) in the treatment of minimal residual disease (MRD), molecular and hematological relapse (MR/HR) after allogeneic stem cell transplantation (SCT) in Philadelphia chromosome positive (Ph ) acute lymphoblastic leukemia (ALL) are scarce.
Sponsorship Statement: Publication of this supplement is sponsored by the European Society for Blood and Marrow Transplantation.
All content was reviewed and approved by the EBMT Committee, which held full responsibility for the abstract selections.
Fifty-eight patients were treated with TKI only (dasatinib, n=50, nilotinib, n=3, ponatinib, n=5), while 82 received additional treatment such as DLI, chemotherapy, or second allo SCT.
Main toxicities of dasatinib were effusion, edema, or other pulmonary complaints (10 - 15% of patients) and infections (13%).